The NIHR BioResource holds genetic data on many of its participants that may be used for data-only research or as a basis of selection to future experimental medicine studies.
To give a sense of the scale of the current holding, this is a snapshot from March 2019:
|Chip/Array||Vendor||Number of samples typed||Number of unique participants||Number of recallable participants||Number of samples available for data re-use|
|Core exome V1.0&V1.1 chip||Illumina||3549||3542||2783||3060|
|MS exome chip||Illumina||1496||1493||1173||1293|
- This table excludes ~7,000 recallable participants recruited to the previous NIHR BioResource – Rare Diseases, who have Whole Genome Sequencing available;
- Not all participants are available at all times – we may only invite each person to 4 studies per year – and not all will want to join any given study;
- However, the number of recallable participants is increasing both as we commission more genotyping – with the revised version of the UK Biobank Axiom (v2.1) chip – and as more participants’ details are added to the central recall database.