Approved studies

NIHR BioResource Supported Studies – national team

Study Number	Study Type	Short Title	Speciality Area	Lead Researcher	Institution or Company
NBR 01	Samples / Data	Affymetrix high-density array NIHR BioResource	Cross-cutting	Prof. John Bradley	University of Cambridge
NBR 03	Samples / Data	Metabalon - Mapping metabolites to their key biochemical pathways	Cross-cutting	Prof. John Bradley	University of Cambridge
NBR 04	Samples / Data	Cholesterol efflux pathways in monocytes and the genetic risk of atherosclerosis	Cardiovascular	Prof. Martin Bennett	University of Cambridge
NBR 05	Volunteer Recall	Investigating changes in memory and attention associated with ageing	Neurological disorders	Prof. Anne Nobre	University of Oxford
NBR 06	Volunteer Recall	Inception - Individuals under investigation for possible IBD or newly diagnosed with IBD	Gastroenterology	Dr Miles Parkes	University of Cambridge
NBR 07	Samples / Data	Validation of genome-wide and targeted genotyping arrays to enable the ascertainment of blood groups of man to a clinical standard	Haematology	Prof. Willem Ouwehand	University of Cambridge
NBR 08	Volunteer Recall	Defining the mechanisms and control of human regulatory T cell function in autoimmunity	Gastroenterology	Prof. Graham Lord	King’s College London
NBR 09	Volunteer Recall	Determining an important functional role for integrins in regulating immune responses in IBD	Gastroenterology	Prof. Mark Travis	University of Manchester
NBR 10	Volunteer Recall	ApoE and gender: Investigation of short-term memory using the Oxford Memory Task app	Neurological disorders	Prof. Masud Husain	University of Oxford
NBR 11	Samples / Data	Progressing from genetics to function and clinical translation in Crohn’s disease & ulcerative colitis	Gastroenterology	Dr Miles Parkes	University of Cambridge
NBR 12	Volunteer Recall	GEM – Genetic, environmental, microbial project	Gastroenterology	Dr Miles Parkes	University of Cambridge
NBR 13	Samples / Data	Genome-wide association studies of circulating blood metabolites	Haematology	Prof. Tim Spector	University of Cambridge
NBR 14	Samples / Data	Discovery of metabolite biomarkers in rare diseases	Rare diseases	Dr Leonardo Bottolo	University of Cambridge
NBR 16	Volunteer Recall	The PREdiCCt (The PRognostic effect of Environmental factors in Crohn’s and Colitis) Study	Gastroenterology	Dr Charlie Lees	University of Edinburgh
NBR 17	Samples / Data	Impute - 50K imputation at Sanger	Cross-cutting	Dr Jyoti Khadake	University of Cambridge
NBR 18	Volunteer Recall	Genetics and metagenome studies in orofacial granulomatosis	Gastroenterology	Dr Natalie Prescott	King’s College London
NBR 20	Samples / Data	PANTS - Genetics of immunogenicity to anti-TNF drugs	Gastroenterology	Dr Tariq Ahmed	University of Exeter
NBR 21	Volunteer Recall	Mechanism linking NOD2 with MHC class I antigen presentation	Gastroenterology	Prof. Alison Simmons	University of Oxford
NBR 22	Samples / Data	CMV infection in inflammatory bowel disease	Gastroenterology	Prof. Holm Uhlig	University of Oxford
NBR 23	Volunteer Recall	The genetic correlates of cognitive flexibility and their links to ideological thinking	Neurological disorders	Prof. Trevor Robbins	University of Cambridge
NBR 24	Volunteer Recall	Investigation of genetic susceptibility markers to arthritic conditions and how they contribute to disease	Arthritis	Dr Annie Yarwood	University of Manchester
NBR 25	Volunteer Recall	Generation of pluripotent stem cell lines to test novel compounds for the treatment of disease	Ophthalmology	Dr David Bunton	REPROCELL Europe Ltd.
NBR 26	Volunteer Recall	Cellular investigation of the role of the GMP reductase in haemoglobin metabolism and red blood cell development	Cardiovascular	Dr Dirk Paul	University of Cambridge
NBR 28	Volunteer Recall	Crohn’s Anal Fistula Quality of Life Scale	Gastroenterology	Dr Alisa Hart	London NW Healthcare NHS Trust
NBR 29	Samples / Data	Assessing whole genome sequencing as a diagnostic test for mitochondrial disease.	Genetics	Prof. Patrick Chinnery	University of Cambridge
NBR 32	Samples / Data	Genotype and Phenotype in Inherited Neurodegenerative Diseases	Neurological disorders	Prof. Patrick Chinnery	University of Cambridge
NBR 33	Volunteer Recall	NOVID - Role of DNA non-coding variants in von Willebrand disease	Genetics	Prof. Patrick Chinnery	University of Cambridge
NBR 34	Volunteer Recall	IBD-Boost Survey: fatigue pain and urgency in IBD	Gastroenterology	Prof. Christine Norton	King’s College London
NBR 35	Volunteer Recall	Pulmonary Arterial Hypertension Associated ATP13A3 Mutations	Cardiovascular	Prof. Nick Morrell	University of Cambridge
NBR 36	Volunteer Recall	VarClot - Effect of DNA non-coding variants in the MYH9 gene region in the regulation of blood clotting.	Haematology	Dr Mattia Frontini	University of Cambridge
NBR 37	Volunteer Recall	AdipO2 - Body fat distribution and diabetes risk: the role of adipose tissue oxygen metabolism	Metabolism	Dr Konstantinos Manolopoulos	University of Birmingham
NBR 38	Samples / Data	Understanding contributions of T cell determining factors in the pathogenesis of IBD	Gastroenterology	Prof. Adrian Hayday	King’s College London
NBR 39	Volunteer Recall	ROVIM - Role of blood group VEL in metabolism.	Metabolism	Dr Mattia Frontini	University of Cambridge
NBR 40	Volunteer Recall	IBD Risk Alleles - Effect of genetic variants associated with risk for inflammatory disease on immune cell phenotype and function.	Gastroenterology	Dr Carl Anderson	Wellcome Sanger Institute
NBR 41	Volunteer Recall	ROTEC - Inherited changes leading to altered levels of a blood protein, tissue factor pathway inhibitor and risk of cardiovascular disease	Haematology	Dr William Astle	University of Cambridge